
ALEJANDRO
GONZALEZ ALVAREZ
PROFESOR/A AYUDANTE DOCTOR/A
Publications (22) ALEJANDRO GONZALEZ ALVAREZ publications
2024
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The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons
British Journal of Pharmacology, Vol. 181, Núm. 17, pp. 3192-3214
2023
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TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
Brain, Vol. 146, Núm. 2, pp. 475-491
2020
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Piezo2 mediates low-threshold mechanically evoked pain in the cornea
Journal of Neuroscience, Vol. 40, Núm. 47, pp. 8976-8993
2019
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The immunosuppressant macrolide tacrolimus activates cold-sensing TRPM8 channels
Journal of Neuroscience, Vol. 39, Núm. 6, pp. 949-969
2018
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GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca 2+ channels
Physiological Reports, Vol. 6, Núm. 17
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Adrenaline stimulates glucagon secretion by Tpc2-Dependent ca2+ mobilization from acidic stores in pancreatic a-Cells
Diabetes, Vol. 67, Núm. 6, pp. 1128-1139
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Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison
Journal of Biological Chemistry, Vol. 293, Núm. 32, pp. 12454-12471
2017
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IKD Current in cold transduction and damage-triggered cold hypersensitivity
Advances in Experimental Medicine and Biology (Springer New York LLC), pp. 265-277
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Role of the excitability brake potassium current IKD in cold allodynia induced by chronic peripheral nerve injury
Journal of Neuroscience, Vol. 37, Núm. 12, pp. 3109-3126
2015
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Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity
Scientific Reports, Vol. 5
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TRP channels in cold transduction
TRP Channels in Sensory Transduction (Springer International Publishing), pp. 185-207
2014
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Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain
Journal of Biological Chemistry, Vol. 289, Núm. 32, pp. 21828-21843
2013
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Insulin hypersecretion in islets from diet-induced hyperinsulinemic obese female mice is associated with several functional adaptations in individual β-cells
Endocrinology, Vol. 154, Núm. 10, pp. 3515-3524
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Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes
Cell Metabolism, Vol. 18, Núm. 6, pp. 871-882
2012
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Functional and structural adaptations in the pancreatic α-cell and changes in glucagon signaling during protein malnutrition
Endocrinology, Vol. 153, Núm. 4, pp. 1663-1672
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Model for glucagon secretion by pancreatic α-cells
PLoS ONE, Vol. 7, Núm. 3
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Role of leptin in the pancreatic β-cell: Effects and signaling pathways
Journal of Molecular Endocrinology, Vol. 49, Núm. 1
2011
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Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets
Diabetologia, Vol. 54, Núm. 4, pp. 843-851
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Regulation of KATP channel by 17β-estradiol in pancreatic β-cells
Steroids, Vol. 76, Núm. 9, pp. 856-860
2010
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A membranotropic region in the C-terminal domain of Hepatitis C virus protein NS4B. Interaction with membranes
Biochimica et Biophysica Acta - Biomembranes, Vol. 1798, Núm. 3, pp. 327-337