Modelado del efecto del ciclo menstrual de una paciente DM1 usando SimBiology

  1. Poveda Perez, Marina 1
  2. Romero-Ante, Juan David 2
  3. Manrique-Cordoba, Juliana 2
  4. Jara-Bravo, Carlos 1
  5. Sabater Navarro, Jose Maria 2
  1. 1 Universitat d'Alacant
    info

    Universitat d'Alacant

    Alicante, España

    ROR https://ror.org/05t8bcz72

  2. 2 Universidad Miguel Hernández de Elche
    info

    Universidad Miguel Hernández de Elche

    Elche, España

    ROR https://ror.org/01azzms13

Aldizkaria:
Jornadas de Automática
  1. Cruz Martín, Ana María (coord.)
  2. Arévalo Espejo, V. (coord.)
  3. Fernández Lozano, Juan Jesús (coord.)

ISSN: 3045-4093

Argitalpen urtea: 2024

Zenbakia: 45

Mota: Artikulua

DOI: 10.17979/JA-CEA.2024.45.10883 DIALNET GOOGLE SCHOLAR lock_openSarbide irekia editor

Laburpena

Type 1 diabetes mellitus (DM1) is an autoimmune disease that results in insufficient insulin production due to the destructionof beta cells in the pancreas. Various mathematical models, such as the one developed by (Dalla Man et al., 2007) and validated by the FDA, have led to a series of studies that have allowed tailoring treatments for patients with DM1 (Manrique-C ́ordobaet al., 2020), allowing a better understanding and control of the disease. In this study, we propose to address the dynamics oftype 1 patients using the Matlab tool SimBiology, taking advantage of its functionalities for the analysis of dynamical systems and biological responses. The model aims to provide a more complete view of how the different stages of the menstrual cycle can affect their blood glucose levels. The simulation results allow analysis of how the model responds to different situations and highlight SimBiology’s graphical capabilities for simulating biological systems. These results improve the understanding of DM1 and highlight the potential of these tools to optimize treatments.

Erreferentzia bibliografikoak

  • Dalla Man, C., Rizza, R. A., Cobelli, C., 2007. Meal simulation model of the glucose-insulin system. IEEE Transactions on biomedical engineering 54 (10), 1740–1749. DOI: https://doi.org/10.1109/TBME.2007.893506
  • Man, C. D., Micheletto, F., Lv, D., Breton, M., Kovatchev, B., Cobelli, C., 2014. The uva/padova type 1 diabetes simulator: new features. Journal of diabetes science and technology 8 (1), 26–34. DOI: https://doi.org/10.1177/1932296813514502
  • Manrique-Córdoba, J., Romero-Ante, J., Samper, J., Vicente, Sabater- Navarro, J., 2024. Modeling the influence of the menstrual cycle on the glucose-insulin system in healthy individuals. Revista Iberoamericana de Automática e Informática industrial 21 (1), 81–89. DOI: https://doi.org/10.4995/riai.2023.18533
  • Manrique-Córdoba, J., Romero-Ante, J., Vivas, A., Vicente, J., Sabater- Navarro, J., 2020. Mathematical modeling of food intakes and insulin infusion in a patient with type 1 diabetes in a closed-loop setting. Iberoamerican Journal of Automatics and Industrial Informatics 17 (2), 156–168. DOI: https://doi.org/10.4995/riai.2019.11161
  • MathWorks, 2024a. Software Matlab. Available online: https://es.mathworks.com/products/matlab.html (accessed on May 15, 2024).
  • MathWorks, 2024b. Software SimBiology. Available online: https://es.mathworks.com/products/simbiology.html (accessed on May 15, 2024).
  • Shack, W., Tam, P., Lardner, T., 1971. A mathematical model of the human menstrual cycle. Biophysical journal 11 (10), 835–848. DOI: https://doi.org/10.1016/S0006-3495(71)86257-4
  • Strotmeyer, E. S., S. A. R. F. J. T. P. B. S. L. . D. J. S., 2003. Menstrual cycle differences between women with type 1 diabetes and women without diabetes. Available online: https://diabetesjournals.org/care/article/26/4/1016/23652/ (accessed on May 15, 2024). DOI: https://doi.org/10.2337/diacare.26.4.1016
  • Zarei, S., M. L. . G. M. A., 2013. Blood glucose levels, insulin concentrations, and insulin resistance in healthy women and women with premenstrual syndrome: a comparative study. Clinical and experimental reproductive medicine. Available online: https://doi.org/10.5653/cerm.201340.2.76 (accessed on May 15, 2024). DOI: https://doi.org/10.5653/cerm.2013.40.2.76
Datuen iturria: Dialnet